In Windows XP, click Start -> Control Panel -> Performance and Maintenance -> System -> Hardware tab -> Device Manager button Locate the device and model that is having the issue and double-click on it to open the Properties dialog box.Ĭlick the Update Driver button and follow the instructions. Visit our Driver Support Page for helpful step-by-step videos Install Drivers Automatically In most cases, you will need to reboot your computer in order for the driver update to take effect. Install blackmagic ultrastudio mini recorder install# If you are having trouble finding the right driver, stop searching and fix driver problems faster with the Automatic Driver Update Utility. Automatic updates could save you hours of time. The Driver Update Utility automatically finds, downloads and installs the right driver for your hardware and operating system. When the scan is complete, the driver update utility will display a results page showing which drivers are missing or out-of-date: Once you download and run the utility, it will scan for out-of-date or missing drivers: It will Update all of your drivers in just a few clicks, and even backup your drivers before making any changes. Next, update individual drivers or all of the necessary drivers with one click. Install blackmagic ultrastudio mini recorder update# Many computer problems are caused by missing or outdated device drivers, especially in Windows 11. Unlocks new features and configuration options in your devices, especially with video cards and gaming devices.Download Now ULTRASTUDIO MINI MONITOR DRIVER If your desktop or laptop is running slow, or keeps crashing or hanging, there is a good chance that updating your drivers will fix the problem.Įnsures your hardware runs at peak performance.įixes bugs so your system will have fewer crashes. Previously, i used the combination of bmd s ultrastudio mini recorder and the ultrastudio mini monitor to handle the acquisition and playback in the world of sdi and hdmi connectivity onset, but i was always forced to connect them at the end of my thunderbolt device chain was more than a bit awkward when working onset. The mini monitor for your work on notify of available driver. Both, the client monitor on the bm mini monitor and the main monitor with the sequence and the source/sequence frames. To address the varied needs that range from one-man-band shops to large facilities, blackmagic design has developed the ultrastudio thunderbolt product family. 4k mini monitor playback device is changing with the future. Post-production technology is changing with the shift to file-based workflows, thunderbolt data paths, and adoption of 4k. Install blackmagic ultrastudio mini recorder drivers#īM Desktop.Īs there are many drivers having the same name, we suggest you to try the driver tool, otherwise you can try one by on the list of available driver below. Now i have the opportunity to repeat the tests using a similar unit from blackmagic, their ultrastudio mini monitor. It is the playback aspect of any blackmagic capture and playback device and of any capture and playback device in general. There are also two audio connections for analog audio input that work with balanced and hifi sources. Such as the latest broadcast technology is a camera. I love aja t-tap with my macbook pro.ĭavinci resolve and additional software are included on an sd card. Perfect for capturing broadcast quality video camera. When i play back my sequence, it's perfectly in sync for a few seconds and then start stuttering until it freezes. Ultra small pocket sized thunderbolt powered playback for sdi and hdmi. Install blackmagic ultrastudio mini recorder driver#īlackmagic ultrastudio mini monitor driver download - for this price point it can't be beat. I love aja, and i love palindromic names, words, sentences, and numbers. Perfect for using low cost hdmi tvs and projectors for monitoring. The mini recorder features sdi and hdmi inputs and a thunderbolt output, and supports resolutions up to 1080p30 / 1080i60. In this video i show you how i fixed the issue i was having connecting my blackmagic ultrastudio mini to my macbook pro.
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Has anyone done Tru Blue? I always liked that on the 2001 Bullitt Mustang. That said, there are a lot of great blues out there, and I’m fine if nobody else get Liquid Blue, simply to keep the total numbers from being even higher for that color. I think the designers feel Liquid Blue really compliments the GT’s lines and overall design, and they want to reserve it for the that model. I also like the fact that Ford isn’t offering the color on any other vehicles. It ranges from a highly-reflective, electric-like blue to a more muted, almost Wedgewood blue, depending on bright sunlight, overcast skies or indoor lighting. The best part of Liquid Blue is how many shades it offers, depending on the lighting conditions. Now that I’ve had it for over a year I have no regrets. HOWEVER - every time I went through the online GT configurator and switched from any other color to Liquid Blue I simply loved how it looked more than any other shade. I never like having a ”common” color, and with the ECP option on the new GT there’s no reason to have a common color. Factory repaint or special order paints may have the 4 digit paint code hand written on the radiator shroud with a wax pen.It was very difficult for me to go with Liquid Blue from the standpoint that it’s one of, if not THE, most popular color on the new GT. Other common color promotional names include Blue, Blue Lightning, and Pinto Blue. Many times it is coded on the factory build sheet which may have stayed with the vehicle after production and is sometimes for older vehicles, found under the interior carpet or rear seat. Paint code Ford M0470 M2J470 M20J470 - blue : This blue automotive paint color is most commonly known as Grabber Blue. For Ford, this longer 4 digit paint code is often not found printed anywhere on the vehicle. The same code ending in the letter "G" is common for interior paints and "D" for under the hood or engine compartment. OK, maybe there is, but here at Jalopnik, we’re big fans of Grabber Blue. Ford production paint codes starting with M are usually followed by a 4 digit number and the letter "A" indicating it is an exterior paint. Grabber Blue is the superior Mustang blue, and there’s no debating that. But, it's still a very light, fun, and eye-catching blue. It's a bit lighter and has more of a metallic sheen. However, this modern version of Grabber Blue is a bit different from the original. Ford did some 71 torino cobras with a richard petty special option also. Grabber Blue is one of the most iconic Mustang paint colors of all time, so it makes total sense to end the run of the S550 with this color available. These longer codes don't change over the years for a particular paint formulation therefore, it is the best code to track the usage of Ford paint. Yes Grabber Blue is a ford color it came out on the Boss 302 / Boss 429 mustang and the Eliminator cougar and probably a few others also. M are production paints, WT and MX are commercial or special order. Grabber paint colors started in 1969 with the Mustang and featured bright hues primarily of yellow, blue, green and orange.įord paint manufacturing codes come in two forms, the short 1 to 3 digit model/year code which changes frequently and the longer 4 digit code which starts with the letters "M", "WT", or "MX". The color formulation has been used between 20, primarily by Ford. 1969 Paint 2 New Lime, 3 Calypso Coral, 4 Silver Jade, 6 Pastel Gray, A Raven Black, B Royal Maroon, C Black Jade, E Aztec Aqua, F Gulfstream Aqua, I Lime Gold, J Grabber Blue, M Wimbledon White, P Winter Blue, S Champagne Gold, T Candy Apple Red, U Grabber Orange, W Meadowlark Yellow, Y Indian Fire Red, Z Grabber Green, D,6 Acapulco Blue, 9,blank Bright Yellow, 9,blank Grabber (Bright) Yellow. This blue automotive paint color is most commonly known as Grabber Blue. Contact Details of Aftab Iqbalįor the purpose of contact you can visit his official website Aftabiqbal. Aftab Iqbal graduated from the Government College University, Lahore in 1985 and later went to America to study history at the San Jose State University, California in 1986. Aftab is the son of the Urdu poet Zafar Iqbal. Personal DetailsĪftab Iqbal was born in September 9, 1961. Mehmood Aslam and Iqra Haris were also part of Aftab Iqbal’s 92 News show and it is titled as “Himaqaten. The show was able to receive huge appreciation from viewers. In this video, UrduPoint anchor Tehmina Sheikh has. His first appearance on TV as host was in Geo Newss Comedy Show, Khabarnaak with Aftab Iqbal. Aftab Iqbal associated with express News as the host of another political-humor talk show name as “Khaberdar with Aftab Iqbal”.Īt the same time he was also hosting show of 92 News channel. Ayesha Jahanzaib is a famous anchor person who has done one of the most popular show Khabarnaak on Geo TV. Khabarnaak is an Urdu and Punjabi comedy television show hosted by Ayesha Jahanzeb alongside Mir Mohammad Ali that airs on GEO News. In 2015 Aftab Iqbal left Geo TV channel and joined Express News. The show was co-hosted by Ayesha Jahanzaib and stared by different famous media celebrities like Saleem Albela, Wajid Khan, Hassan Murad, Lucky Dear, Sherry Nanha, Abid Farooq and others. KARACHI: Pakistans most interesting and popular comic plus political show 'Khabarnaak' is about to start in a new and unique way from this Thursday. Some reports claimed that he had conflicts with Dunya News management.Īfter leaving Dunya News, he joined Geo News as the host of the Urdu and Punjabi Comedy television show, Khabarnaak. The show was co-hosted by the two other famous media personalities Sohail Ahmed as Azizi and Najia Baig. He hosted the famous political-humor talk show “Hasb-e-Haal” for more than 2 years. He used to share his expert opinions on the talk show Meray Mutabiq along with host Maria Memon. Warraich most popular programme was hosted Ek Din Geo k Sath on Geo News every Saturday and Sunday. Electronic Media CareerĪftab Iqbal started his career in electronic media from Dunya News channel in 2008. Sohail Warraich is a prominent Pakistani journalist, television host, analyst and media personality. He also writes columns in “The News” titled Buk-up and worked as the article writer for “Newsweek Pakistan”. They are used for fair purpose to educate and entertain.Aftab Iqbal has written for a number of publications, including the Urdu language Nawa-i-Waqt. 1)This video has no negative impact on the original works (It would actually be positive for them) 2)This video is also for teaching purposes.Īll the images, clips and music used belongs to the owner. Non-profit, educational or personal use tips the balance in favor of fair use. Fair use is a use permitted by copyright statute that might otherwise be infringing. Giving everyone the news from entertainment, sports, politics, since and technology, business and world news.Ĭopyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. If you like my video Then Hit the Like Button Share your thoughts in comment box Watch full video Do Subscribe my Channel 'CMC Home'for more videos. The video is made for entertainment purposes only that is based on my own content and material.This channel doesnot promote and encourages any illegal activity and all the content provided by this channel is totally meant for educational and entertainment purposes only.ĬMC Home is a YouTube channel that shares the Latest Celebrity Gossip, Actors News, Celebrity Interviews, Exclusive Stories, Red Carpet Fashion and Events, Celebrity Trends, Movie News, Photos and Videos, Style and Updates From the World of Entertainment Involving Your Favourite Stars and breaking news without hurting sentiments of any religion, community cast or any individual person at one click. Do Subscribe my Channel "CMC Home"for more videos.įor More Videos Please Subscribe My Channel Now, Henderson, the character in the book-is, was, one of those people who was born with everything going for them, at least it looked that way on paper. "A short time ago, a friend gave me a book called Henderson the Rain King and I started to read it but I never got finished I got halfway through and sort of left the whole plot up in the air, literally, and got inspired to write the next song. There’s enchantment and dis-enchantment, what we’re taught to believe things are and what they really are." In late 1967, she introduced the song like this: But in this song there are only two sides to things… there’s reality and I guess what you might call fantasy. In most cases there are both sides to things and in a lot of cases there are more than just both. "This is a song that talks about sides to things. Interestingly, she gave the same introduction - word for word - on Octoat the Second Fret in Philadelphia: Joni introduces the song this way at the White Swan in Leicester, England on September 16, 1967. And so I got this idea 'from both sides now.' There are a lot of sides to everything, and so the song is called "From Both Sides, Now." I was reading a book, and I haven't finished it yet, called "Henderson the Rain King." And there's a line in it that I especially got hung up on that was about when he was flying to Africa and searching for something, he said that in an age when people could look up and down at clouds, they shouldn't be afraid to die. It - I should tell people a little bit about it. What have we got here? "Night in the City," "Circle Game" - oh, "From Both Sides, Now." I'm really glad somebody requested that, because that's a very new song, and I've been driving everybody crazy by playing it twice and three times a night. Gene: Want to do some of the requested songs? Joni in conversation with Gene Shay, "Folklore Program" March 12, 1967: Well something's lost, but something's gained They shake their heads, they say I've changed it’s an amazing app but it’s just those two things that need to get fixed.I've looked at clouds from both sides now and when it closes, I have to open it again and then I have to type my password and I have to do that all over again so if those things would get fixed, I think we would all be happier about it. I don’t like how it closes itself because it kind of wastes my time while I’m trying to look for a song lyrics. lyrics I alsothink those things should get fixed at some point and I think that if those things get fixed, it will save me more time and I will have more time to find my favorite lyrics so anyway, if those things would get fixed, I think we would all be much happier about that I don’t really like signing in so many times after I close it and how it just closes after 30 seconds when I open another app, it just closes itself. I also don’t like how after 30 seconds of it being in the background of other apps, it just closes and I have to re-open it and re-do everything again when I am trying to search for a song. I feel like if they would fix this the app would work better. and I have to re-type in my password and email. and it’s really good to use when you want to know the lyrics to songs but however, I don’t really like how when I close the app I have to re-sign in again. It is really good for finding the lyrics to songs you like. Overall the profile tab seems worthless now, but could be better in the future. If you sign into google it takes your google account picture and makes it your profile picture without giving you a way to change it later. They make it out like you can personalize your profile based on your style of music, which seems cool, but is not really the case. When you download the app you can sign into a profile like any other app now but in Genius your profile is almost meaningless. It’s a bummer because i can’t find a way to get around it.ģ. It makes for a cool background but every time i want to make one right before i save it to my camera roll the app decides to crash. There is a feature in the app where in a song you can take a picture given to you from the artist or your own picture and take lyrics from a particular song and put it over the picture. When you watch the videos in the app and you try to flip your device sideways the video will stay in the upright position (even with lock rotation on allowing you to freely move your portrait), which is annoying since the picture is already as small as it is.Ģ. But a few things that are really irritating and annoying are:ġ. I love the interface and the way you navigate throughout the app. Pretty good overall but has some glitches You can learn more about what’s new in today’s update on the Kaleidoscope blog. It’s worth noting that the app doesn’t have any subscriptions or in-app purchases. The selected layers will blend to form a kaleidoscope pattern. With the layers selected, click on the Blending Mode drop down menu (red arrow below) and select the Lighten option. Kaleidoscope 3 is available on the Mac App Store for $149.99, and you can get a 15-day free trial version on its official website. Select the top three layers in the layers panel by holding down the shift key and clicking on Layers 1, 2, and 3. In addition to the Safari extension, Kaleidoscope 3.3 comes with a new extension for Visual Studio Code that lets developers “open files, git changesets, and git merges directly from VSCode.” Other improvements coming with the update include the ability to view invisible characters in code, as well as overall bug fixes. Next time you find yourself in a debugging situation where you need to inspect an object with many properties, remember Kaleidoscope and ksdiff(), which allows you to quickly save the current state. We even use this not only for comparing output, but for quickly getting content into another app, ready for copy and paste use later on. You can also use the “ksdiff” function in the JavaScript console to find bugs in your code. With just a click, you can get a full copy of a website’s source code. The new Safari extension allows developers to easily analyze and compare the HTML or CSS code of a webpage using Kaleidoscope. Following a major update last October with a new interface and support for M1 Macs, the app was updated today with new Safari extensions for web developers. Kaleidoscope is a popular and powerful Mac app for users who constantly need to compare the differences between files and folders. I have requested cancellation of my membership but they insist on 45 days' notice before they will refund the deposit thereby guaranteeing they get another billing cycle as well as to hold onto my deposit for another 45 days. I have left several messages, send multiple emails with complaints without a single call back or acknowledgment. There is no one available for complaints. We pay for the meal plan and each time we go the park more and more food locations are not open. Over the last year the quality of the park has gone downhill. Used to love this place, have been season pass holders for many seasons, and members for the last year and a half. Remember this is not a real zoo, so only a few but a good walkthrough area. We went with teens who absolutely love all the thrill rides here, but there is plenty for younger kids too. There are water fountains throughout the park. You should definitely buy the season drink cup as it pays for itself if you go there more than once. Any kiosk with food is ridiculously expensive and might not have a scanner to give you the pass discount. Parking is expansive at $40 and is about 15 min walk from the entrance.įood is typical of these kind of parks. Disappointed too that October fest closed by about 7 on a Saturday. All in all, don’t waste your time going for fright fest, haunted houses or on a Saturday when everyone else is there. Didn’t buy the haunted attractions pass as I’ve heard it’s mediocre and sometimes not all of the haunted houses even open. Lines were 2-3 hrs for some of the rides. Some of the food areas that were indoor were poorly ventilated so it was better to be outside in 90 degree weather. Went on a Saturday and unfortunately a hot day. I had considered taking some family members that wouldn’t be going on roller coasters but who I thought would enjoy the extra stuff from fright fest. Next came in October to experience fright fest. This is probably the best time to go with short lines. Near perfect weather and this time is considered in summer peak so open on a weekday. Some opened late ( remember at this time of year park is only open 6-7 hrs) and some of the food kiosks didn’t have scanners to give you discount for pass. Went in April initially and at that time we had a fun trip with the kids for the most part but a lot of rides were closed. We’ve done this and have had different experiences. Worth it if you get a pass and can go multiple times. Stacking warfare also helps with the damage, so you'll still deal okay-ish damage. While strength-based weapons or the finesse-based daggers won't deal optimal damage because you're intelligence based, they deal the right kind of damage for a necromancer, which is physical. The options are: One-handed strength-based melee weapon (sword, mace, hammer.), wand or dagger. Picking this option leaves us with the choice of the specific one-handed weapon you use alongside the shield. One-handed weapon + shield is a very good choice as the skill Bouncing Shield scales with the armour value of the shield and warfare, meaning you'll do perfectly optimised damage with it.If you decide to go for a physical weapon your damage will be far lower than for a strength or finesse based character and dealing magical damage won't work well with your spells which deal physical damage exclusively so auto-attacks become basically useless. So you can either god for a melee weapon that deals physical damage and scales with warfare but with either strength or finesse instead of intelligence or you go for for a weapon that scales with intelligence but not with warfare and also deals magic damage.īoth options are not a perfect fit. There is no weapon in the vanilla version of the game that scales with intelligence and warfare and deals physical damage. Like many here already know, an intelligence-based Necromancer has some issue when picking a fitting weapon. Tl dr: What do you think is the best weapon choice for an intelligence-based Necromancer and why? Vendor Prices, Bartering & Attitude Formula Level Up: Attribute, Skill & Talent Point Breakdown The Quick Questions and Looking for Group Threads exist for a reason, use them. >!This is spoilery!< to get This is spoilery Submissions should relate to Divinity Original Sin or other works of Larian Studios.ĭo not put spoilers in the title of your post and mark your posts. Join up with a friend to play online in co-op and make your own adventures with the powerful RPG toolkit. Gather your party and get ready for a new, back-to-the-roots RPG adventure! Discuss your decisions with companions fight foes in turn-based combat explore an open world and interact with everything and everyone you see. Welcome To The Divinity: Original Sin Subreddit! Looking for a Group to play with? Try this thread || Discussion Overview There is a lockdown in the Netherlands from 19 December 2021 to (at least) 14 January 2022. The number of registered new infections has risen strongly. Since the end of November 2021, the SARS-CoV-2 Omicron variant is spreading in parts of Europe (i.e. curfew in a context of emergence of the British variant, the worst riots in 40 years broke out across the country. On 23 January 2021, as the government imposed a nationwide 9:00 p.m. In March 2020, Prime Minister Mark Rutte called for herd immunity as an important method to stop the pandemic. The government strategy on pandemic control has been criticised for the refusal to acknowledge the role of asymptomatic spread and the role of masks in preventing spread, as well as for the lack of testing capacity, in particular during the first half of 2020. On the advice of the Outbreak Management Team (OMT), under supervision of Jaap van Dissel, measures were taken by the Third Rutte cabinet for the public health to prevent the spread of this viral disease, including the "intelligent lockdown". The first death occurred on 6 March, when an 86-year-old patient died in Rotterdam. As of 31 January 2021, there are 978,475 confirmed cases of infections and 13,998 confirmed deaths. The virus was confirmed to have reached Europe on 24 January 2020, when the first COVID-19 case was identified in Bordeaux - France. It involved a 56-year-old Dutchman who had arrived in the Netherlands from Italy. The virus reached the Netherlands on 27 February 2020, when its first COVID-19 case was confirmed in Tilburg. The COVID-19 pandemic in the Netherlands has resulted in 8,623,210 confirmed cases of COVID-19 and 22,986 deaths. 4,029,669 fully vaccinated without booster (13 March 2022).It features a young boy who has ditched his Superman and Spiderman toys in favour of another superhero: nurses! The Daily Mirror says the 1-metre-high piece will be auctioned off for charity. "Game Changer" appeared on the corridor wall of Southampton hospital yesterday. The early trial has offered hopeful results in what scientists hope could be a preventative cure one day.įinally, Banksy has paid tribute to British health workers in his latest artwork. They have found that Winter's more acute antibodies successfully fought off the SARS and MERS viruses and found that those antibodies also staved off the new virus that causes Covid-19. The New York Times explains that llamas produce two types of antibodies, unlike one in humans. Scientists in Belgium are hoping a 4-year-old, eyelash-batting llama called Winter could be crucial in the fight against coronavirus. It's the reason why Der Taggespiegel is more cautious on its front page today: evoking a difficult new start. Counties will decide on whether to reopen cinemas and theatres, but the openings will be revoked if infections rise. German schools, restaurants, cafes, hotels and sports will gradually recommence this month. "Permitted" is the somewhat optimistic headline in the Hamburger Morgenpost. Merkel says Germany is ready to reopen most aspects of its society and economy, albeit with social distancing and masks in place. According to German health experts, new daily infections are in the hundreds now. There's some joy in the German press today after Chancellor Angela Merkel’s announcement that the country has passed the first phase of coronavirus. 30-day VHF omnidirectional range (VOR) equipment check required for IFR flight (14 CFR part 91, section 91.171).Static system and encoder certification, within the preceding 24-calendar months, required for instrument flight rules (IFR) flight in controlled airspace (14 CFR part 91, section 91.411).Transponder certification within the preceding 24-calendar months (14 CFR part 91, section 91.413).100-hour inspection, if the aircraft is operated for hire (14 CFR part 91, section 91.409(b)).Annual inspection within the preceding 12-calendar months (Title 14 of the Code of Federal Regulations (14 CFR) part 91, section 91.409(a)). The owner/operator is primarily responsible for maintenance, but the pilot is (solely) responsible for determining the airworthiness (and/or safety) of the airplane for flight. So all you have to do is go over it with your CFI and log the ground time. Pilot in command (PIC), Aircraft, enVironment, and External pressuresįortunately Chapter 2 of the Airplane Flying Handbook tells you exactly what is required by the aircraft part of PAVE. Emotions-A pilot who experiences an emotionally upsetting event should refrain from flying until the pilot has satisfactorily recovered. Fatigue-Am I tired and not adequately rested? Fatigue continues to be one of the most insidious hazards to flight safety, as it may not be apparent to a pilot until serious errors are made.Ħ. Alcohol-Have I been drinking within 8 hours? Within 24 hours?ĥ. While the regulations list medical conditions that require grounding, stress is not among them.Ĥ. Stress-Stress causes concentration and performance problems. Medication-Am I taking any medicines that might affect my judgment or make me drowsy?ģ. Illness-Am I sick? Illness is an obvious pilot risk.Ģ. Preflight your passengers by preparing them for the possibility of delay and diversion, and involve them in your evaluation process.įrom your private pilot training you are probably familiar with two pneumonics.ġ. (1) For an airplane category rating with a single-engine class rating:įrom the Pilots Handbook of Aeronautical Knowledge Chapter 2: Two of them involve procedures prior to beginning the flight. By incorporating IMSAFE into their pre-flight routine, pilots can ensure they are fit to fly safely, reduce stress levels, and make better decisions in the air.Commercial applicants are required to log ground or flight training in 11 areas. In conclusion, IMSAFE is an essential part of aviation safety that can help pilots prioritize their physical and mental well-being before every flight.
With the advent of new treatments, biomarker testing of newly diagnosed tumors is pivotal. “I remember the time when we had one line of therapy now we are talking about multiple options in second and later lines, so we can tailor our regimens, not only to disease characteristics but also to patient characteristics.” These treatment advances have greatly expanded the treatment landscape. Tumor histology remains a critical factor in decision-making biomarker testing for HER2 is performed only on adenocarcinomas, whereas drug selection for a given line of therapy for squamous cell carcinoma and adenocarcinoma may differ based on PD-L1 expression levels, she said. Because these malignancies are now being categorized according to HER2 status, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) status, and PD-L1 expression, biomarker testing is a necessary first step at diagnosis to facilitate treatment management across the therapy continuum. Matkowskyj, MD, PhD, Associate Professor in the Department of Pathology and Laboratory Medicine and Director of the UW Carbone Cancer Center Translational Sciences BioCore. Lurie Comprehensive Cancer Center of Northwestern University, at the NCCN 2021 Virtual Annual Conference.įurthermore, the growing importance of biomarkers in these cancers was emphasized by Kristina A. Mulcahy, MD, Professor, Department of Hematology-Oncology, Northwestern University, and Director, Gastrointestinal Oncology Program, Robert H. Denlinger, MD, Chief, Division of Gastrointestinal Medical Oncology, and Co-Director, Survivorship Program, and Associate Professor, Department of Hematology-Oncology, Fox Chase Cancer Center, and Mary F. Trials supporting the use of these improved therapies, and their application in the clinic for certain subgroups, was presented by Crystal S. These new drugs include immune checkpoint inhibitors (ICIs), the HER2-directed agent trastuzumab-deruxtecan (T-DXd), the monoclonal antibody ramucirumab, and the cytotoxic agent trifluridine/tipiracil. ICIs are now moving into the adjuvant setting as well, and a new recommendation is nivolumab use after preoperative chemoradiation and surgery in patients who have residual disease identified at the time of their R0 resections.įor the treatment of gastric and esophageal cancers, recent studies have demonstrated robust findings for new drugs that, as a consequence, are becoming FDA-approved and added to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Esophageal and Esophagogastric Junction Cancers and for Gastric Cancer. T-DXd is another new second-line option for HER2-positive esophageal, GEJ, and gastric adenocarcinomas. Recently, ICIs have been incorporated into the first-line treatment of HER2-negative advanced esophageal, gastroesophageal junction (GEJ), and gastric cancers, in addition to second-line treatment of advanced esophageal and GEJ cancer of squamous histology. These agents convey varying degrees of benefit depending on treatment line, PD-L1 expression, HER2 expression, and tumor histology. In addition to pembrolizumab and nivolumab, new treatment options include trastuzumab-deruxtecan (T-DXd), ramucirumab, and trifluridine/tipiracil. For the treatment of gastric and esophageal cancers, several pivotal trials-especially those evaluating immune checkpoint inhibitors (ICIs)-have altered the treatment landscape and led to changes in the NCCN Guidelines. |
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